1.
Bioconjug Chem
; 35(2): 147-153, 2024 02 21.
Artigo
em Inglês
| MEDLINE
| ID: mdl-38266192
RESUMO
While dual-display DNA-encoded chemical libraries (DELs) are increasingly employed for ligand discovery, some of their fundamental properties have not yet been studied in-depth. Aided with fluorescence polarization experiments, we demonstrate that dual-display DELs are intrinsically asymmetrical entities, and we deduce practical guidelines to perform better-informed on-DNA hit validation from these libraries.